CRISPR-Cas Systems in Precision Medicine: Advances, Challenges, and Future Perspectives
DOI:
https://doi.org/10.64137/XXXXXXXX/IJMSD-V1I1P105Keywords:
CRISPR-Cas, Personalized medicine, Gene drive technology, Synthetic biology, Genome editing, Genetic disorders, Cancer therapy, Antiviral therapy, Gene therapy, Ethical considerationsAbstract
The development of precision medicine was greatly helped by the CRISPR-Cas systems’ strong ability to edit DNA. They make it simpler and more precise to correct DNA mistakes, which can help treat genetic disorders, cancer, and infections. The article compiles current information on CRISPR-Cas in precision medicine, covering its uses, recent achievements, and the issues that still need to be solved. We also consider what CRISPR-Cas systems may do in the future, such as their ability to aid personalized medicine and the ethical issues that require attention
References
[1] Yang, Y., Xu, J., Ge, S., & Lai, L. (2021). CRISPR/Cas: advances, limitations, and applications for precision cancer research. Frontiers in medicine, 8, 649896.
[2] Azeez, S. S., Hamad, R. S., Hamad, B. K., Shekha, M. S., & Bergsten, P. (2024). Advances in CRISPR-Cas technology and its applications: Revolutionising precision medicine. Frontiers in Genome Editing, 6, 1509924.
[3] Ilahibaks, N. F., Hulsbos, M. J., Lei, Z., Vader, P., & Sluijter, J. P. (2022). Enabling precision medicine with CRISPR-Cas genome editing technology: a translational perspective. In Genome Editing in Cardiovascular and Metabolic Diseases (pp. 315-339). Singapore: Springer Nature Singapore.
[4] Nidhi, S., Anand, U., Oleksak, P., Tripathi, P., Lal, J. A., Thomas, G., ... & Tripathi, V. (2021). Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives. International journal of molecular sciences, 22(7), 3327.
[5] Liu, W., Li, L., Jiang, J., Wu, M., & Lin, P. (2021). Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics. Precision clinical medicine, 4(3), 179-191.
[6] Zaychikova, M. V., Danilenko, V. N., & Maslov, D. A. (2020). CRISPR-Cas systems: Prospects for use in medicine. Applied Sciences, 10(24), 9001.
[7] Ravichandran, M., & Maddalo, D. (2023). Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling. Frontiers in Genetics, 14, 1273994.
[8] Gohil, N., Bhattacharjee, G., Lam, N. L., Perli, S. D., & Singh, V. (2021). CRISPR-Cas systems: challenges and prospects. Progress in Molecular Biology and Translational Science, 180, 141-151.
[9] Barbour, A., Glogauer, J., Grinfeld, L., Ostadsharif Memar, R., Fine, N., Tenenbaum, H., & Glogauer, M. (2021). The role of CRISPR‐Cas in advancing precision periodontics. Journal of Periodontal Research, 56(3), 454-461.
[10] Das, S., Bano, S., Kapse, P., & Kundu, G. C. (2022). CRISPR-based therapeutics: a new paradigm in cancer precision medicine. Molecular Cancer, 21(1), 85.
[11] Xing, H., & Meng, L. H. (2020). CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment. Acta Pharmacologica Sinica, 41(5), 583-587.
[12] Pickar-Oliver, A., & Gersbach, C. A. (2019). The next generation of CRISPR–Cas technologies and applications. Nature reviews Molecular cell biology, 20(8), 490-507.
[13] Marino, N. D., Pinilla-Redondo, R., Csörgő, B., & Bondy-Denomy, J. (2020). Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies. Nature methods, 17(5), 471-479.
[14] Zhang, S., Wang, Y., Mao, D., Wang, Y., Zhang, H., Pan, Y., & Huang, P. (2023). Current Trends in Clinical Trials Involving CRISPR/Cas Systems. Frontiers in medicine, 10, 1292452.